DNA Replication and Genome Instability
The Barlow lab studies how replication stress induces genome instability and contributes to cancer initiation and progression using the mouse immune system as a model. Rapidly proliferating cell types—such as B and T lymphocytes—are particularly vulnerable to replication stress.
Using genome-wide mapping techniques, we have identified genomic loci that are hypersensitive to replicative stress, and are undertaking studies to determine the molecular and genetic determinants underlying their fragility.
These studies will help illuminate how spontaneous DNA damage arises in proliferating cells, with the aim of promoting earlier identification of tumors and developing more effective cancer treatments.
Using genome-wide mapping techniques, we have identified genomic loci that are hypersensitive to replicative stress, and are undertaking studies to determine the molecular and genetic determinants underlying their fragility.
These studies will help illuminate how spontaneous DNA damage arises in proliferating cells, with the aim of promoting earlier identification of tumors and developing more effective cancer treatments.